myvariant.variant_info
mock data$0.001 / callGet Variant Annotation Details
Retrieve comprehensive annotation for a single genetic variant by its dbSNP rsID (e.g. "rs671") or HGVS genomic notation. Returns complete annotation from 30+ integrated databases: ClinVar clinical significance and disease conditions, CADD pathogenicity scores (raw + PHRED), gnomAD exome and genome allele frequencies across ancestry groups (AFR, EUR, EAS, AMR, ASJ), SnpEff predicted functional consequences with HGVS coding and protein notations, dbSNP allele frequency data, COSMIC somatic mutation records, CIViC clinical interpretations, and genomic coordinates in both GRCh37 (hg19) and GRCh38 (hg38). Essential for variant interpretation pipelines, pharmacogenomics analysis, and clinical variant classification (ACMG guidelines).
Input schema
Comma-separated annotation fields to retrieve. Default: dbsnp,clinvar,cadd,gnomad_exome,gnomad_genome,snpeff,vcf,chrom,hg19. Optional: dbnsfp (functional predictions), cosmic (somatic), civic (clinical), gwassnps (GWAS associations), hg38 (GRCh38 coordinates). Use "all" for complete annotation.
Variant identifier — dbSNP rsID (e.g. "rs58991260"), or HGVS genomic notation (e.g. "chr7:g.140453134A>T" — use URL-encoded form when needed). rsIDs are preferred as they are stable across assemblies. Obtain IDs from myvariant.search results.
Call via REST
curl -X POST https://unifyapi.pro/api/call/myvariant.variant_info \
-H "Authorization: Bearer uak_live_..." \
-H "Content-Type: application/json" \
-d '{"fields":"<fields>","variant_id":"<variant_id>"}'